Hct 116 is atra sensitive or atra resistant

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August undefined, 2024

WebNational Center for Biotechnology Information WebApr 25, 2024 · By performing RNA-Seq analysis of ATRA-resistant and ATRA-sensitive cells, we have obtained a whole-transcriptome perspective of how gene expression …

Identification of FDA-approved Drugs Targeting Breast …

WebFeb 24, 2024 · VPA Promotes ATRA-Induced Autophagy in ATRA Sensitive and Resistant Cell Lines. We and others have previously shown that ATRA induces autophagy in the APL NB4 cell line . Here, we investigate whether VPA can enhance the autophagy induced by ATRA in NB4 cells and whether it can help to initiate autophagy in the ATRA-resistant … WebCopyright by Eunyoung Park 2007 - The University of Texas at Austin かっこいい画像

Retinol Inhibits the Growth of All-Trans-Retinoic Acid–Sensitive …

WebRAR-mutated HCT-116 colon cancer cells were incubated for 3, 12, or 24 h in the presence or absence of 1 μM ATRA. (A) qPCR for CysLT2R expression in HCT-116 cells. Data are normalized to HPRT-1. WebOct 1, 2002 · The long-term maintenance of resistance in ATRA-free culture and the presence of a genetic change mediating resistance argue that this cell line is truly ATRA resistant, not transiently insensitive.57 Figure 2A confirms the expression of PML/RARα fusion protein in NB4-MRA1 cells and shows the ATRA-induced PML/RARα protein … WebMay 1, 2024 · To assess whether UBE2L6 expression is important for leukemic cell differentiation—two cell line models were employed: the human APL cell line NB4 and its ATRA‐resistant NB4R counterpart, as well as the ATRA‐sensitive human AML HL60 cells along with their ATRA‐resistant subclone—HL60R. ATRA strongly induced UBE2L6 in … カッコイイ苗字海外

Retinoic acid receptor antagonist BMS453 inhibits the growth

Retinol inhibits the growth of ATRA-resistant human

WebMay 8, 2013 · Notably, PHF8 expression was much lower in an ATRA-resistant APL cell line than in its ATRA-sensitive parental cell line, suggesting that PHF8 regulates ATRA sensitivity in APL cells. ... Although it remains to be shown whether PHF8 expression is decreased in ATRA-resistant patients, these findings provide insight into the molecular … HCT116 cells have a mutation in codon 13 of the KRAS proto-oncogene, and are suitable transfection targets for gene therapy research. The cells have an epithelial morphology and can metastasize in xenograft models. When transducted with viral vectors carrying the p53 gene, HCT116 cells remain arrested in the G1 phase. The proliferation of HCT116 colonies was found to be inhibited by 5-Fu/P85 copolymer micelles. Furthermore, it was found that the knockout of MARCH2 limited … pato pateta letraWebCT.GOV-Connecticut's Official State Website かっこいい苗字海外の反応

"WebNov 19, 2010 · Acute promyelocytic leukemia (APL) represents 3.3%-17.4% of acute leukemia in adults. With the application of all-trans retinoic acid (ATRA), more than 85% patient can achieve complete remission, however, high rates of relapse still exist if ATRA is used alone. Primary resistance of ATRA in PML-RARα positive APL is rare during … " - Hct 116 is atra sensitive or atra resistant

Hct 116 is atra sensitive or atra resistant

An Effective Model of the Retinoic Acid Induced HL-60

WebTo discern the underlying mechanism for the treatment response of the xenografts, in vitro HCT-116 cell cultures were investigated with enzymatic assays, cell cycle analysis, and … WebOct 30, 2024 · Results. We constructed an effective model of ATRA-induced HL-60 differentiation which described signaling and gene expression events following the …

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WebHCT-15 (A) HCT-116 (B), SW620 (C ), and WiDR (D ) cells were seeded and treated with 0, 0.1, 1, or 10 Amol/L ATRA or retinol. All treatments were performed in duplicate. Cells … WebBreast cancer cells which were resistant to atRA, were also resistant to BMS453. Normal human breast cells were most sensitive to the anti-proliferative effects of BMS453. These results indicate that in some breast cells RAR-dependent transactivation is not necessary for retinoids to inhibit growth.

WebFeb 24, 2024 · Figure 1 Valproic acid (VPA) promotes all-trans-retinoic acid (ATRA)-mediated myeloid differentiation in ATRA sensitive and ATRA resistant, acute promyelocytic leukemia (APL) cell lines (NB4 and NB4R).NB4 and NB4R cell lines were treated with either ATRA (1 μM) or VPA (1mM) alone or in combination for 72 hours. … WebWe examined the ability of retinol to inhibit the growth of ATRA-sensitive (HCT-15) and ATRA-resistant (HCT-116, SW620, and WiDR) human colon cancer cell lines. Retinol …

WebCopyright by Eunyoung Park 2007 - The University of Texas at Austin Webby ATRA in combination with activation of PPRE by PPARγ, ligand CDDO will induce de-silencing of downstream genes and induce differentiation in ATRA-sensitive and ATRA-resistant APL. As a model, we used APL-derived NB4 cells, its ATRA-resistant clone MR2 (Rosenauer 1996, ref. 23) and an in vivo APL model

WebJul 8, 2013 · The colon cancer cell lines Caco-2, SW480 (ATRA-sensitive), and HCT-116 (ATRA-resistant) [ 30] were grown in Dulbecco’s modified Eagle medium with 100 μM non-essential amino acids, RPMI 1640, and McCoy’s 5A medium, respectively.

WebNov 1, 2005 · We examined the ability of retinol to inhibit the growth of ATRA-sensitive (HCT-15) and ATRA-resistant (HCT-116, SW620, and WiDR) human colon cancer cell … pato pato ganso instructivoWebChapter 2: Retinol Inhibits the Growth of All-Trans-Retinoic Acid-. Sensitive and -Resistant Colon Cancer Cells through a Retinoic Acid. Receptor-Independent Mechanism. ABSTRACT pato pato ganso juego de patioWebAug 28, 2013 · Ful-R cells, a fulvestrant resistant cell line derived from a single cell clone of MCF-7, were more sensitive to ATRA than MDA-MB-436 and MDA-MB-231 cells, which … かっこいい筆文字書き方WebApr 26, 2024 · Abstract While all-trans retinoic acid (ATRA) is an essential therapy in the treatment of acute promyelocytic leukemia (APL), an aggressive subtype of acute myeloid leukemia, nearly 20% of APL patients are resistant to ATRA. pato pato巧拼團購WebMany researches indicate that the mechanism of ATRA-resistance is related to lack of some proteins synthesized by interferon (IFN). This study was to explore the possibility and the possible mechanism of treating ATRA-resistant APL with IFN in … カッコイイ英語類語WebHCT 116 Cell Line. HCT116 is a human colorectal carcinoma cell line initiated from an adult male. The cells are adherent with an epithelial morphology. Following implantation into … pato pateta vinicius de moraisWebBreast cancer cells which were resistant to atRA, were also resistant to BMS453. Normal human breast cells were most sensitive to the anti-proliferative effects of BMS453. … かっこいい英語